The Kazua Nakao's group, pioneer of the natriuretic peptide type C (CNP) physiology in cartilage and bone, has presented a new study where they explored the local roles of both CNP and its receptor guanylil cyclase B (GC-B, also known as NPRB) in the growth plate.
The investigators from University of Kyoto developed animal models where either CNP or GC-B were deleted (knocked-out) from growth plate chondrocytes. The study was important to provide more evidence of the influence of the CNP cascade in bone growth. It also may help understanding the consequences of the rare mutations affecting NPRB.
This study has been presented at the 6th International Conference on cGMP: Generators, Effectors and Therapeutic Implications, Erfurt, Germany, 28-30 June 2013. Unfortunately, only the abstract is currently available. It is reasonable to expect that the authors will pursue the publication of the complete results.
Here goes the complete reference (access is free):
Nakao K et al. Impact of local CNP/GC-B system in growth plates on endochondral bone growth. Paramacol Toxicol 2013; 14 (Suppl 1):48.
We have reviewed CNP and its signaling cascade in a number of articles in this blog. Just take a look at the English page (link at the top of the page), where you can find a list of all articles published here.